9-hydroxy Stearic Acid

SKU: orb2901000

Description

9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ～66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	3384-24-5
MW	300.48
Purity	>98% (HPLC)
Formula	C₁₈H₃₆O₃
SMILES	C(C(CCCCCCCCC)O)CCCCCCC(O)=O
Target	HDAC
Solubility	In Vitro: DMSO : ≥ 100 mg/mL (332.80 mM)

Bioactivity

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In Vitro

Cell line: HT29 cell. Concentration: 100 μM. Incubation time: 24 h. Result: Decreased S-phase activity by 50.2% compared with untreated controls, and the growth inhibition was associated with a strong arrest in G0/G1. Cell line: HT29 cell. Concentration: 100 μM. Incubation time: 24 h. Result: Increased the expression of p21WAF1。 Cell line: HT29 cell. Concentration: 100 μM. Incubation time: 24 h. Result: Induced p21WAF1 tanscript.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

HDAC

Protocol Information

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Purity:	99.70% (May vary between batches)
CAS Number:	3384-24-5
MW:	300.48
Formula:	C₁₈H₃₆O₃