9-hydroxy Stearic Acid

SKU: orb1693195

Description

9-Hydroxy Stearic Acid is the bioactive metabolite of 9-PAHSA, generated via carboxyl ester lipase. In vitro studies demonstrate its role in inhibiting HDAC1 expression and suppressing proliferation, inducing G0/G1 phase arrest in HT-29 colon cancer cells, highlighting its utility in metabolic and cancer research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3384-24-5
• MW: 300.48
• Purity: 99.70% (May vary between batches)
• Formula: C₁₈H₃₆O₃
• SMILES: C(C(CCCCCCCCC)O)CCCCCCC(O)=O
• Target: HDAC
• Solubility: Chloroform:Soluble;10% DMSO+90% Corn Oil:2.5 mg/mL (8.32 mM);DMSO:60 mg/mL (199.68 mM)

Bioactivity

• In Vitro:
  9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA . It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 µM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates. It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 µM.1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

9hydroxy Stearic Acid, 9-hydroxy Stearic Acid, 9 hydroxy Stearic Acid, HDAC1

Compound Identifiers

PubChem CID

9570127