7-Dehydrocholesterol

SKU: orb1302447

Description

This product, 7-Dehydrocholesterol (provitamin D3), is a key sterol shown to suppress endogenous cholesterol synthesis in Smith-Lemi-Opitz syndrome (SLOS) fibroblast models. It serves as a crucial research tool for studying SLOS pathophysiology, cholesterol homeostasis, and sterol metabolism in both cellular and biochemical assays.

Research Area

Cell Biology

Key Properties

• CAS Number: 434-16-2
• MW: 384.7
• Purity: >98%
• Formula: C₂₇H₄₄O
• SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• Target: Endogenous Metabolite
• Solubility: Soluble in DMSO (up to at least 5 mg/ml with warming) or in Ethanol (up to 10 mg/ml)

Bioactivity

• In Vitro:
  7-Dehydrocholesterol, a biosynthetic precursor of cholesterol and vitamin D3, is found in high concentrations in the skin. Upon UV irradiation, it converts to pre-vitamin D3 and is also exposed to exogenous radical sources and oxygen.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Provitamin D3

Compound Identifiers

PubChem CID

439423