7-Chlorokynurenic acid

SKU: orb1940836

Description

7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.(In Vivo):In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.

Key Properties

• CAS Number: 18000-24-3
• MW: 223.61
• Purity: >98% (HPLC)
• Formula: C₁₀H₆ClNO₃
• SMILES: O=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1
• Target: GluR
• Solubility: In Vitro: DMSO : 16.67 mg/mL (74.55 mM)

Bioactivity

• In Vivo:
  Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline

Quick Database Links

Gene Symbol

GluR