7-Chlorokynurenic acid

SKU: orb1310038

Description

7-Chlorokynurenic acid is a selective NMDA receptor glycine site antagonist (IC50 = 0.56 µM) and a glutamate reuptake inhibitor (Ki = 0.59 µM). It is widely used in neuroscience research to study excitatory neurotransmission, neuropathic pain mechanisms, and has demonstrated antinociceptive effects in animal models following central administration.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 18000-24-3
• MW: 223.61
• Purity: 99.72%
• Formula: C₁₀H₆ClNO₃
• SMILES: OC(=O)c1cc(O)c2ccc(Cl)cc2n1
• Target: iGluR,GluR,NMDAR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.47 mM);DMSO:15 mg/mL (67.08 mM)

Bioactivity

• Target IC50:
  Glycine B coagonist site of NMDA receptor:0.56 μM(ki)|Reuptake of glutamate:（ki）0.59 μM
• In Vivo:
  In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

reuptake of glutamate, NMDA receptor, Glycine B coagonist site of NMDA receptor, Glutamate receptor, 7-chloro-4-hydroxy-2-carboxyquinoline, 7-Chlorokynurenic acid, 7-CKA

Compound Identifiers

PubChem CID

1884