5-Chloro-2'-deoxyuridine

SKU: orb1307119

Description

5-Chloro-2'-deoxyuridine is a thymidine analog widely used in research to investigate DNA damage mechanisms, particularly those induced by hypochlorous acid. It serves as a tool in both in vitro and in vivo studies to examine mutagenesis and the stability of nucleic acid precursors.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 50-90-8
• MW: 262.65
• Purity: 99.54% (May vary between batches)
• Formula: C₉H₁₁ClN₂O₅
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(Cl)c(=O)[nH]c1=O
• Target: Others
• Solubility: DMSO:125 mg/mL (475.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.23 mM)

Bioactivity

• In Vitro:
  The mammalian cells incorporate the analog into DNA when 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In this study, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CldU, 5 Chloro 2' deoxyuridine, 5-Chloro-2'-deoxyuridine, 5Chloro2'deoxyuridine, 5-Chlorodeoxyuridine, inhibit, Inhibitor

Compound Identifiers

PubChem CID

65510