2',3'-cGAMP

SKU: orb3029215

Description

2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1441190-66-4
• MW: 674.41
• Purity: 98.65%
• Formula: C₂₀H₂₄N₁₀O₁₃P₂
• SMILES: O[C@H]1[C@@]2([C@@H](O[C@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@H]([C@@H]3O)N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])N6C7=C(N=C6)C(=O)N=C(N)N7)[H]
• Target: Endogenous Metabolite,Immunology/Inflammation related,cGAS,COX,STING,IFNAR
• Solubility: H2O:≥ 40 mg/mL

Bioactivity

• Target IC50:
  STING:3.79 nM(Kd)
• In Vitro:
  2',3'-cGAMP contains two distinct phosphodiester bonds: one linking the 2'-hydroxyl group of GMP with the 5'-phosphate of AMP, and another connecting the 3'-hydroxyl group of AMP with the 5'-phosphate of GMP .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMP, 2',3' cGAMP, 2',3'cGAMP, 2',3'-cGAMP, Human Endogenous Metabolite

Quick Database Links

Gene Symbol

Endogenous Metabolite,Immunology/Inflammation related,cGAS,COX,STING,IFNAR