187-1, N-WASP inhibitor

SKU: orb1679371

Description

This small molecule inhibitor targets N-WASP by locking it in an autoinhibited conformation, thereby blocking PIP2-induced actin polymerization with an IC50 of ~2 µM. It is a valuable research tool for studying cytoskeletal dynamics in vitro and has been used to investigate pathways involving Cdc42 and Arp2/3 complex signaling in cellular models.

Research Area

Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: Arp2/3 Complex
• CAS Number: 380488-27-7
• MW: 1784.13
• Formula: C₉₆H₁₂₂N₁₈O₁₆
• SMILES: O=C1N2C(C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N5[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N7C(C(=O)N[C@H](CC8=CC=CC=C8)C(=O)N[C@@H](CC9=CC=CC=C9)C(=O)N%10[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CC%11=CC=CC=C%11)(CCC%10)[H])(CCC7)[H])(CCC5)[H])(CCC2)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171666594