1-Hydroxyanthraquinone

SKU: orb1940321

Description

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.(In Vitro):1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.(In Vivo):Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.

Key Properties

• CAS Number: 129-43-1
• MW: 224.215
• Purity: >98% (HPLC)
• Formula: C₁₄H₈O₃
• SMILES: Oc1cccc2C(=O)c3ccccc3C(=O)c12
• Target: DNA/RNA Synthesis
• Solubility: In Vitro: DMSO : 16.67 mg/mL (74.35 mM)

Bioactivity

• In Vivo:
  1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats. Animal model: Thirty rats. Dosage: 1% HA in diet. Administration: Diet. Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becoming mori bund between 335 and 462 days.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis