1-Hydroxyanthraquinone

SKU: orb1303862

Description

1-Hydroxyanthraquinone is a genotoxic and carcinogenic compound isolated from Morinda officinalis. It is a valuable research tool for studying DNA damage response mechanisms, as it potently induces a robust cellular DNA repair response in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 129-43-1
• MW: 224.21
• Purity: 98.83% (May vary between batches)
• Formula: C₁₄H₈O₃
• SMILES: OC1=CC=CC2=C1C(=O)C1=C(C=CC=C1)C2=O
• Target: DNA/RNA Synthesis
• Solubility: Chloroform:30 mg/mL (133.8 mM);DMSO:3.93 mg/mL (17.53 mM)

Bioactivity

• In Vivo:
  Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.
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• In Vitro:
  1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, 1 Hydroxyanthraquinone, 1Hydroxyanthraquinone, 1-Hydroxyanthraquinone, carcinogenic, Inhibitor, inhibit, RNA Synthesis, RNASynthesis, repair, pneumonia, tumor

Compound Identifiers

PubChem CID

8512