Zoliflodacin

SKU: orb1296233

Description

Zoliflodacin

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 1620458-09-4
• MW: 487.44
• Purity: 99.82% (May vary between batches)
• Formula: C₂₂H₂₂FN₅O₇
• SMILES: [H][C@]12[C@H](C)O[C@H](C)CN1c1c(CC22C(=O)NC(=O)NC2=O)cc2c(noc2c1F)N1[C@@H](C)COC1=O
• Target: Topoisomerase|||DNA/RNA Synthesis|||DNA gyrase|||Antibacterial
• Solubility: DMSO:135 mg/mL (276.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.21 mM)

Bioactivity

• Target IC50:
  S. aureus:0.25 μg/mL (MIC90)
• In Vitro:
  Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Topoisomerase, RNASynthesis, RNA Synthesis, Zoliflodacin, AZD0914, AZD-0914, Bacterial, AZD 0914, DNA gyrase, DNA Synthesis, DNA/RNA Synthesis, DNAgyrase, DNASynthesis, Inhibitor, ETX 0914, ETX0914, ETX-0914, inhibit

Compound Identifiers

PubChem CID

76685216