ZNL0325

SKU: orb2815504

Description

ZNL0325 is a pyrazolo[1,2-a]pyrimidine-based covalent probe that engages kinases via a reversed C3 orientation, targeting a cysteine at the αD-1 position. Its acrylamide warhead enables irreversible inhibition of BTK, EGFR, BLK, and JAK3, supporting kinase mechanism studies and inhibitor development in biochemical and cellular assays.

Key Properties

• Molecular Weight: 316.36
• Formula: C₁₅H₂₀N₆O₂
• SMILES: CC(C)(C)N1C2=NC=NC(N)=C2C(OC3CN(C(C=C)=O)C3)=N1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170836104