ZLD1039

SKU: orb1698904

Description

ZLD1039 is a highly selective, orally active EZH2 inhibitor that potently inhibits wild-type and mutant PRC2 enzymatic activity. It demonstrates efficacy in suppressing breast tumor growth and metastasis in preclinical models, making it a valuable tool for oncology research targeting epigenetic mechanisms.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1826865-46-6
• MW: 612.8
• Purity: 99.82% (May vary between batches)
• Formula: C₃₆H₄₈N₆O₃
• SMILES: CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
• Target: Histone Methyltransferase
• Solubility: DMSO:9 mg/mL (14.69 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (0.82 mM)

Bioactivity

• In Vitro:
  ZLD1039 inhibited the H3K27me3 and H3K27me2 levels in MCF-7 (0.25~2 μM, 4 days) and MDA-MB-231 (1~4 μM, 4 days) cells in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Methyltransferase, HistoneMethyltransferase, EZH2, ZLD 1039, ZLD1039, ZLD-1039

Compound Identifiers

PubChem CID

132517142