ZIM

SKU: orb1737470

Description

ZIM, a norbornene-modified derivative of 4-Aminoantipyrine, acts as a DNA-damaging agent, inducing genomic instability, cell death, and phagocytosis. Its mechanism supports investigation as a potential chemotherapeutic, with applications in cancer research for both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 301298-87-3
• MW: 349.38
• Purity: 99.13% (May vary between batches)
• Formula: C₂₀H₁₉N₃O₃
• SMILES: CN1N(C(=O)C(N2C(=O)C3C4CC(C=C4)C3C2=O)=C1C)C1=CC=CC=C1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:10 mg/mL (28.62 mM)

Bioactivity

• In Vivo:
  ZIM (i.p., 12, 24, and 48 mg/kg) significantly reduces chromosomal micronucleus frequency at all doses in adult male Swiss mice, exhibiting a chemopreventive effect within 24 to 72 hours, and achieving damage reduction between 38.36% and 83.26%. Additionally, ZIM at these concentrations lowers liver and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX, with a decrease in liver damage in the CIS group of 79.27%, 75.20%, and 52.84%, respectively, and 62.06%, 59.44%, and 77.80% in the DOX group. The reduction in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, DNA/RNA Synthesis, RNASynthesis, RNA Synthesis, ZIM

Compound Identifiers

PubChem CID

5096714