Zatolmilast

SKU: orb1309910

Description

Zatolmilast (BPN14770) is a potent allosteric inhibitor of PDE4D, exhibiting IC50 values of 7.8 nM and 7.4 nM against the PDE4D7 and PDE4D3 isoforms, respectively. This compound is a valuable research tool for investigating PDE4D's role in neurobiology and cognitive function, with applications in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1606974-33-7
• MW: 405.8
• Purity: 99.31% (May vary between batches)
• Formula: C₂₁H₁₅ClF₃NO₂
• SMILES: OC(=O)Cc1ccc(Cc2cc(nc(c2)C(F)(F)F)-c2cccc(Cl)c2)cc1
• Target: PDE
• Solubility: DMSO:260 mg/mL (640.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.32 mM)

Bioactivity

• Target IC50:
  PDE4D7:7.8 nM|PDE4D3:7.4 nM
• In Vivo:
  BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus . BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3 mg/kg .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BPN 14770, BPN14770, BPN-14770, inhibit, Inhibitor, Zatolmilast, PDE4D3, PDE4D7, Phosphodiesterase (PDE), phosphodiesterase

Compound Identifiers

PubChem CID

90111638