Z4P

SKU: orb2565031

Description

Z4P is a blood-brain barrier permeable IRE1 inhibitor (IC50=1.13 µM). It demonstrates synergistic efficacy with Temozolomide, suppressing glioblastoma tumor growth and preventing recurrence in preclinical models, highlighting its potential for neuro-oncology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 2361760-87-2
• MW: 312.41
• Purity: 98.99%
• Formula: C₁₉H₂₄N₂O₂
• SMILES: O=C(NC1=CC(=CC=C1C)C)NC(C)CCC2=CC=C(O)C=C2
• Target: IRE1
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (10.56 mM);DMSO:80 mg/mL (256.07 mM)

Bioactivity

• In Vivo:
  Z4P crosses the BBB and, at 300 μg/kg i.p. daily for 28 days, significantly reduces tumor size in GBM xenograft mice. Combined with TMZ, Z4P causes near-complete tumor regression with no evident toxicity.
• In Vitro:
  Z4P inhibits IRE1α RNase activity in GBM cells (U87, RADH87, U251, UTMZ), reducing XBP1s and SPARC expression and showing dose-dependent antiproliferative effects. At 25 μM (48 h), Z4P significantly suppresses GBM cell viability and enhances the efficacy of TMZ.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Z4-P

Compound Identifiers

PubChem CID

146132000