Z433927330

SKU: orb1308926

Description

Z433927330 is a potent and selective small-molecule inhibitor of Aquaporin-7 (AQP7), exhibiting an IC50 of 0.2 µM. This compound is a valuable research tool for investigating AQP7 function in adipocyte glycerol metabolism and its implications for metabolic disorders in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1005883-72-6
• MW: 364.4
• Purity: 99.78%
• Formula: C₂₀H₂₀N₄O₃
• SMILES: CCOC(=O)c1ccc(NC(=O)NCc2ccc(cc2)-n2cccn2)cc1
• Target: Others,Aquaporin
• Solubility: DMSO:280 mg/mL (768.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.72 mM)

Bioactivity

• Target IC50:
  AQP9 (mouse):~1.1 µM |AQP3 (mouse):~0.7 µM |AQP7 (mouse):~0.2 µM
• In Vitro:
  Z433927330 inhibits glycerol permeability(IC50 : 0.6 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mAQP3, mAQP7, mAQP9, Inhibitor, inhibit, Z433927330, Z-433927330, Z 433927330

Compound Identifiers

PubChem CID

51116434