ZVAD-FMK

SKU: orb1301152

Description

Z-VAD(OMe)-FMK is a cell-permeable, irreversible pan-caspase inhibitor that also covalently inhibits the deubiquitinase UCHL1 by targeting its active site. It is widely used in apoptosis and proteostasis research, applicable in both in vitro and in vivo models to study programmed cell death and neurodegenerative pathways.

Research Area

Cell Biology

Key Properties

• Biological Activity: Caspase inhibitor (pan-specific)(Cell permeable methyl ester)
• Target: Protease
• CAS Number: 187389-52-2
• MW: 467.5
• Purity: >98%
• Formula: C₂₂H₃₀FN₃O₇
• SMILES: COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF

Storage & Handling

• Storage: -20°C
• Form/Appearance: Lyophilized
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZVAD(OMe)-FMK

Compound Identifiers

PubChem CID

5497174