YYA-021

SKU: orb1300931

Description

YYA-021

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 144217-65-2
• MW: 317.43
• Purity: 95.82% (May vary between batches)
• Formula: C₁₈H₂₇N₃O₂
• SMILES: Cc1ccc(NC(=O)C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1
• Target: HIV Protease,gp120/CD4
• Solubility: DMSO:11 mg/mL (34.65 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.3 mM)

Bioactivity

• Target IC50:
  HIV:8.4 μM
• In Vivo:
  In rats and rhesus macaques, YYA-021 (i.v.) shows moderate half-lives, wide tissue distribution and relatively high distribution volumes.
• In Vitro:
  YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD4, inhibit, Human immunodeficiency virus, Gp120, gp120, HIV, HIVProtease, HIV Protease, Inhibitor, YYA 021, YYA021, YYA-021

Compound Identifiers

PubChem CID

3107635