YS-370

SKU: orb1301227

Description

YS-370 is an orally bioavailable small molecule that inhibits P-glycoprotein (P-gp) and moderately inhibits CYP3A4. It reverses multidrug resistance to agents like paclitaxel and colchicine in vitro and demonstrates enhanced antitumor efficacy in combination with paclitaxel in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2470908-79-1
• MW: 663.6
• Purity: 98.06%
• Formula: C₃₇H₃₅BrN₄O₃
• SMILES: COc1cc2ncnc(-c3c(-c4ccccc4)n(Cc4ccccc4Br)c4ccccc34)c2cc1OCCCN1CCOCC1
• Target: P-gp
• Solubility: DMSO:6 mg/mL (9.04 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YS370, YS-370, YS 370, P-gp, Pgp

Compound Identifiers

PubChem CID

162679251