YLF-466D

SKU: orb1708200

Description

YLF-466D (C24) is a novel small molecule activator of AMP-activated protein kinase (AMPK). Its ability to inhibit platelet aggregation makes it a valuable research tool for studying thrombosis, cardiovascular diseases, and metabolic disorders in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1273323-67-3
• MW: 465.93
• Purity: 97.74% (May vary between batches)
• Formula: C₂₉H₂₀ClNO₃
• SMILES: OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1
• Target: AMPK
• Solubility: DMSO:90 mg/mL (193.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.08 mM)

Bioactivity

• In Vitro:
  The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, C 24, C24, C-24, YLF-466D

Compound Identifiers

PubChem CID

51033997