Xylitol

SKU: orb1310465

Description

Xylitol (Ribitol) is a pentitol sweetener produced via the reduction of xylose. It exhibits non-cariogenic properties and is used in research on carbohydrate metabolism, dental health studies, and as a sugar substitute in cell culture and animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87-99-0
• MW: 152.15
• Purity: 99.76% (May vary between batches)
• Formula: C₅H₁₂O₅
• SMILES: C(C(CO)O)(C(CO)O)O
• Target: ATG,Endogenous Metabolite,Autophagy,Antibacterial
• Solubility: H2O:197.2 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (16.43 mM);DMSO:45 mg/mL (295.76 mM)

Bioactivity

• In Vivo:
  Xylitol triggers the release of insulin in dogs and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug.
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• In Vitro:
  Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs.
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• Cell Research:
  In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D-Xylitol, 16277-71-7, Adonite, Adonitol, Autophagy, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, inhibit, Xylite, Xylitol, Ribitol

Compound Identifiers

PubChem CID

827