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xStAx-VHLL

SKU: orb1985068

Description

This selective β-catenin degrader utilizes a stapled peptide (xStAx) linked to a VHL ligand to induce targeted protein degradation. It effectively reduces β-catenin levels in vitro in HEK293T and colorectal cancer cells and demonstrates in vivo efficacy by inhibiting tumor growth in APCmin/+ mouse models and patient-derived organoids.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetAPC/C,Wnt/beta-catenin,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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xStAx-VHLL (orb1985068)

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