XEN723

SKU: orb1308935

Description

XEN723 is a potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), exhibiting IC50 values of 45 nM in mouse and 524 nM in HepG2 cell assays. This small molecule is a valuable research tool for investigating SCD1's role in metabolic diseases, including obesity and fatty liver, in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1072803-08-7
• MW: 425.48
• Purity: 99.50% (May vary between batches)
• Formula: C₂₁H₂₀FN₅O₂S
• SMILES: Cc1nc(sc1C(=O)NCc1cccnc1)N1CCN(Cc2ccc(F)cc2)C1=O
• Target: Stearoyl-CoA Desaturase (SCD),Dehydrogenase
• Solubility: DMSO:100 mg/mL (235.03 mM)

Bioactivity

• Target IC50:
  SCD1:45 nM(in Mouse)|SCD1:524 nM( in HepG2 cell)
• In Vitro:
  XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively). XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, XEN723, XEN-723, XEN 723, SCD, SCD1 in HepG2 cell, SCD1 in Mouse, SCD1, StearoylCoADesaturase, StearoylCoADesaturase(SCD), Stearoyl-CoA Desaturase, StearoylCoA Desaturase (SCD), Stearoyl-CoA Desaturase (SCD)

Compound Identifiers

PubChem CID

25095149