HRO761

SKU: orb1745126

Description

HRO761 is a potent and selective inhibitor of the Werner syndrome RecQ DNA helicase (WRN), a promising target for synthetic lethality in microsatellite unstable (MSI) cancers. It is a valuable research tool for in vitro and in vivo studies in oncology, particularly for investigating therapeutic strategies against MSI-high colorectal and gastric cancers.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2869954-34-5
• MW: 702.08
• Purity: 99.62%
• Formula: C₃₁H₃₁ClF₃N₉O₅
• SMILES: C(C(NC1=C(Cl)C=C(C(F)(F)F)C=C1)=O)N2C=3N(C(=O)C(=C2CC)N4CCN(C(=O)C=5C(O)=C(C)N=CN5)CC4)N=C(N3)C=6CCOCC6
• Target: DNA/RNA Synthesis
• Solubility: DMSO:99.7 mg/mL (142.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.7 mM)

Bioactivity

• Target IC50:
  WRN ATPase:100 nM|SW48 cells:50 nM|DLD1 WRN-KO cells:> 10 μM
• In Vitro:
  HRO761 exhibits an IC50 value of 100 nM for WRN ATPase, and demonstrates GI50 values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WRN helicase, Werner syndrome RecQ helicase-IN-1, RNASynthesis, RNA Synthesis, DNA Synthesis, DNASynthesis, HRO-761

Compound Identifiers

PubChem CID

166140536