VX-984

SKU: orb1709849

Description

VX-984 (M9831) is a brain-penetrant, oral DNA-PK inhibitor that blocks non-homologous end joining (NHEJ) repair of DNA double-strand breaks. It is utilized in preclinical research, particularly in studies investigating glioblastoma and non-small cell lung cancer, both in vitro and in vivo.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 1476074-39-1
• MW: 415.49
• Purity: 97.65% (May vary between batches)
• Formula: C₂₃H₂₁D₂N₇O
• SMILES: [2H]c1nc(C)nc([2H])c1-c1cc(NC[C@@H](C)c2cccc3c(ccnc23)C(=O)NC)ncn1
• Target: DNA-PK
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.2 mM);DMSO:9 mg/mL (21.66 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

M 9831, M9831, M-9831, DNAPK, DNA-PK, VX984, VX-984, VX 984

Compound Identifiers

PubChem CID

72188357