VU6004909

SKU: orb2277687

Description

VU6004909 is a potent orthosteric mGlu5 receptor modulator with an EC50 of 25.7 nM. It has demonstrated efficacy in preclinical models, reversing MK-801-induced hyperlocomotion and cognitive deficits, making it a valuable research tool for studying schizophrenia and related neurological disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 1860797-76-7
• MW: 378.35
• Purity: 96.68% (May vary between batches)
• Formula: C₂₁H₁₅FN₂O₄
• SMILES: O=C(NC1=CC=C(C=C1F)N2C(=O)C3=CC=C(C=C3C2=O)C)C=4OC=CC4C
• Target: GluR
• Solubility: DMSO:4 mg/mL (10.57 mM)

Bioactivity

• Target IC50:
  mGlu1 (human):25.7 nM (EC50)|mGlu1 (rat):31 nM (EC50)
• In Vitro:
  VU6004909 is a blood-brain barrier-penetrating orthosteric modulator of mGlu1 with half-maximal effective concentrations (EC50) of 25.7 nM and 31 nM for human- and rat-derived mGlu1, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU 6004909

Compound Identifiers

PubChem CID

127026165