VU 0357121

SKU: orb1300523

Description

VU 0357121

Research Area

Neuroscience

Key Properties

• CAS Number: 433967-28-3
• MW: 305.32
• Purity: 99.99%
• Formula: C₁₇H₁₇F₂NO₂
• SMILES: CCCCOC1=CC=C(C=C1)C(=O)NC1=CC=C(F)C=C1F
• Target: GluR
• Solubility: DMSO:30.5 mg/mL (99.9 mM);Ethanol:30.5 mg/mL (99.9 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.55 mM)

Bioactivity

• Target IC50:
  mGluR5:30 nM(EC50)
• In Vitro:
  VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, mGluR5, mGluR, Metabotropic glutamate receptors, inhibit, VU0357121, VU-0357121, VU 0357121

Compound Identifiers

PubChem CID

2296132