VRT-532

SKU: orb1699008

Description

VRT-532 (CFpot-532) is a small molecule CFTR modulator used in cystic fibrosis research. It has been shown in studies to upregulate arylsulfatase B (ARSB) activity, thereby reducing pathological accumulations of glycosaminoglycans like chondroitin-4-sulfate in cellular and animal models of CF.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 38214-71-0
• MW: 250.3
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₄N₂O
• SMILES: CC1=CC=C(O)C(=C1)C1=NNC(=C1)C1=CC=CC=C1
• Target: CFTR
• Solubility: DMSO:2.51 mg/mL (10.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4 mM)

Bioactivity

• In Vitro:
  VRT-532 binds directly to G551D-CFTR in isolated systems, thereby improving its channel function and increasing its ATPase rate. VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CFTR, CFpot532, CFpot-532, CFpot-532), F508del-CFTR, G551D-CFTR, VRT532, VRT-532, VRT 532

Compound Identifiers

PubChem CID

781239