VnP-16

• Catalog Number: orb1479250
• Category: Proteins
• Description: β1 and αvβ3 integrin signaling modulator; Peptides.
• Modifications: C terminal amide.
• Structure: H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2
• Target Areas: Integrin receptors
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 1648.85 Da
• Formula: C₈₂H₁₁₂N₂₀O₁₇
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: Vitronectin derived bioactive peptide, IG 060IG060
• Background: VnP-16 is a peptide corresponding to residues 270-281 of human vitronectin, which exerts an anti-osteoporotic effect via β1 and αvβ3 integrin signaling. VnP-16 promotes bone formation by accelerating osteoblast differentiation through direct interaction with β1 integrin followed by FAK activation, while inhibiting bone resorption through restraint of JNK-c-Fos-NFATc1 induced osteoclast differentiation and αvβ3 integrin-c-Src-PYK2 mediated resorption. In a mouse model of estrogen deficiency induced osteoporosis, VnP-16 reverses ovariectomy induced bone loss by increasing osteoblast differentiation and promoting bone formation, while decreasing osteoclastogenesis and inhibiting bone resorption.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.