VK3-OCH3

SKU: orb1220972

Description

2-[(2-Methoxy)ethylthio]-3-methyl-14-na is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

Key Properties

• CAS Number: 255906-59-3
• MW: 262.32
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄O₃S
• SMILES: COCCSC1=C(C)C(=O)c2ccccc2C1=O
• Target: Others
• Solubility: DMSO:25mg/mL(95.3 mM)

Bioactivity

• In Vitro:
  VK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 μM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively. VK3-OCH3 (1, 3, 10 μM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells. VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-[(2-Methoxy)ethylthio]-3-methyl-14-na

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Gene Symbol

Others