Vitamin K

SKU: orb1306969

Description

Vitamin K (Kephton) is an essential cofactor for the activation of coagulation factors and proteins like osteocalcin and matrix-Gla protein. It is widely used in research on hemostasis, vascular calcification, and bone metabolism in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 12001-79-5
• Purity: 97.00% (May vary between batches)
• Target: Endogenous Metabolite
• Solubility: DMSO:61.25 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL

Bioactivity

• In Vivo:
  Vitamin K supplementation is beneficial in improving insulin sensitivity and glucose tolerance, reducing the risk of type 2 diabetes, and preventing insulin resistance. The recommended intake of adequate vitamin K is 90 micrograms per day for women and 120 micrograms per day for men . Vitamin K deficiency leads to an increase in hypocarboxylated osteocalcin, a decrease in bone mineral density, and an increased probability of fracture. Vitamin K supplementation reduces undercarboxylated osteocalcin and improves bone turnover curves .
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• In Vitro:
  Vitamin K plays an important role in nervous system. Vitamin K facilitates the bioactivation of protein Gas6 and protein S, ligands of the TAM family (Tyro3, Axl and Mer) receptor tyrosine kinases. In the brain, vitamin K is involved in the synthesis of sphingolipids .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vitamin K1(20), Vitamin K, EndogenousMetabolite, Endogenous Metabolite, Microbial Metabolite, Kephton

Quick Database Links

Gene Symbol

Endogenous Metabolite