Vidarabine

SKU: orb1308405

Description

Vidarabine is a nucleoside antibiotic derived from Streptomyces antibioticus with demonstrated antineoplastic and broad-spectrum antiviral activity. It has been used in research applications, including in vitro studies against herpesviruses and in vivo models for investigating antiviral mechanisms and efficacy.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 5536-17-4
• MW: 267.24
• Purity: 100.00% (May vary between batches)
• Formula: C₁₀H₁₃N₅O₄
• SMILES: O[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O
• Target: DNA/RNA Synthesis|||Antibiotic|||Tyrosine Kinases|||Nucleoside Antimetabolite/Analog|||HSV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.48 mM);H2O:3 mg/mL (11.23 mM);DMSO:75 mg/mL (280.65 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HSV2:11.3 μg/mL (IC50)|HSV1:9.3 μg/mL (IC50)
• In Vivo:
  Vidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite.
• In Vitro:
  Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adenine Arabinoside, 9-b-D-Arabinofuranosyladenine, 9-beta-D-Arabinofuranosyladenine, 9-β-D-Arabinofuranosyladenine, Ara-A, Arabinosyladenine, Analog, Antibiotic, DNA polymerase, DNA Synthesis, DNASynthesis, HSV, Inhibitor, Herpes simplex virus, inhibit, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Orthopoxvirus, RNASynthesis, RNA Synthesis, Vira-A, Vidarabine, TyrosineKinases, Tyrosine Kinases

Compound Identifiers

PubChem CID

21704