VHL Ligand-Linker Conjugates 17

SKU: orb1987590

Description

VHL Ligand-Linker Conjugates 17 are bifunctional chemical tools consisting of a VHL E3 ligase ligand connected to a linker, designed for constructing PROTAC degraders. They serve as key intermediates in synthesizing potent degraders like ARD-266, which effectively degrades the androgen receptor in cancer research, as demonstrated in both cellular and in vivo studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 654.75
• Formula: C₃₇H₄₂N₄O₇
• SMILES: O=C(C[C@@H](C1=CC=CC=C1)NC([C@H]2N(C([C@H](C(C)C)C3=CC(C)=NO3)=O)C[C@H](O)C2)=O)N(CC4)CCC4C#CC5=CC=C(C(O)=O)C=C5
• Target: E3 Ligase Ligand-Linker Conjugates,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145925678