Vevorisertib

SKU: orb1691729

Description

Vevorisertib

Research Area

Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1416775-46-6
• MW: 586.73
• Purity: 98.88%
• Formula: C₃₅H₃₈N₈O
• SMILES: O=C(N(C)C1CCN(C2=CC=CC(=C2)C3=NC4=C(N=C(C5=CC=CN=C5N)N4C6=CC=C(C=C6)C7(N)CCC7)C=C3)CC1)C
• Target: Akt,Serine Protease
• Solubility: DMSO:4 mg/mL (6.82 mM)

Bioactivity

• Target IC50:
  Akt3:1.31 nM (IC50)|Akt3:1.31 nM|Akt2:0.81 nM (IC50)|Akt2:0.81 nM|Akt1:0.55 nM (IC50)|Akt1:0.55 nM
• In Vivo:
  Vevorisertib (10-120 mg/kg) has dose-dependent antitumor activity in AKT1-E17K mutant endometrial patient xenograft (PDX) models.
• In Vitro:
  Vevorisertib binds to wild-type AKT1 and mutant AKT1-E17K with Kd of 1.2 nM and 8.6 nM, respectively, and inhibits pAKT(S473) in 293T cells transiently transfected with AKT1-E17K.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARQ751, ARQ-751, ARQ 751, Vevorisertib

Compound Identifiers

PubChem CID

71138858