Verucerfont

SKU: orb1220317

Description

Verucerfont is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .(In Vivo):Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailed Post hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline).

Key Properties

• CAS Number: 885220-61-1
• MW: 406.48
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₆N₆O₂
• SMILES: CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1
• Target: CRF Receptor
• Solubility: DMSO:86.7 mg/mL (213.29 mM)

Bioactivity

• In Vivo:
  Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20, 140] = 6.4, P<0.001). Accordingly, detailed Post hocanalysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK561679 | NBI77860

Quick Database Links

Gene Symbol

CRF Receptor