Venlafaxine hydrochloride

SKU: orb1223468

Description

Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 99300-78-4
• MW: 313.86
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₈CLNO₂
• SMILES: OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.[H]Cl
• Target: 5-HT Receptor
• Solubility: Ethanol: 55.5 mg/mL (176.83 mM); Water: 55.5 mg/mL (176.83 mM); DMSO: 55.5 mg/mL (176.83 mM)

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats weighing 180-230 grams. Dosage: 10, 30, 100 mg/kg. Administration: IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.). Result: Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED50 values of 12 and 94 mg/kg i.p. , respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wy 45030

Quick Database Links

Gene Symbol

5-HT Receptor