Velpatasvir

SKU: orb1226413

Description

Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.HCV Infection Phase 3 Clinical.

Key Properties

• CAS Number: 1377049-84-7
• MW: 883.0018
• Purity: >98% (HPLC)
• Formula: C₄₉H₅₄N₈O₈
• SMILES: O=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC5=C(C6=CC7=CC=C8C(NC([C@H]9N(C([C@H](C(C)C)NC(OC)=O)=O)[C@@H](C)CC9)=N8)=C7C=C6OC5)C=C4)N3)C[C@H](COC)C2)=O
• Target: HCV
• Solubility: DMSO: 146.66 mg/mL (Need ultrasonic and warming)

Bioactivity

• In Vivo:
  Animal model: CCl4-induced non-HCV rat model. Dosage: 10 mg/kg/d alone, or in combination with Sofosbuvir (20 mg/kg/d). Administration: p.o. Result: Decreased the levels of TNF-a, NF-κB and IL-6 in serum and hepatic tissues. Inhibited hepatic stellate cells (HSCs).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GS-5816 | GS 5816 | GS5816

Quick Database Links

Gene Symbol

HCV