Vanzacaftor

SKU: orb1982961

Description

Vanzacaftor is a CFTR modulator that improves protein processing and trafficking to enhance chloride channel function. It is a key research tool for investigating CFTR correction in both cellular and animal models of cystic fibrosis, supporting the development of novel therapeutics.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2374124-49-7
• MW: 617.76
• Purity: 99.14%
• Formula: C₃₂H₃₉N₇O₄S
• SMILES: C(COC1=NN(C=C1)C=2N=C3N4C(C)(C)C[C@@](C4)(CCCN=C5NC(S(=O)(=O)NC(=O)C3=CC2)=CC=C5)[H])C6C7(C68CC8)CC7
• Target: CFTR,Chloride channel
• Solubility: DMSO:80 mg/mL (129.5 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (5.34 mM)

Bioactivity

• In Vitro:
  When the concentration of Vanzacaftor was 0-10 μM, it stimulated K⁺ secretion in Homo sapiens bronchial epithelial cells (HBEs) at low micromolar concentrations, with an EC₅₀ value of 4.4 μM for this effect being inhibited by Paxilline . Treatment with 1 μM, 5 μM, and 10 μM Vanzacaftor significantly enhanced the αBKCa current in HEK cells, and this current could be blocked by Paxilline . When 5 μM Vanzacaftor acted on hippocampal primary neurons, it reduced their action potential discharge frequency and altered neuronal excitability .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VX121, VX-121

Compound Identifiers

PubChem CID

139399801