USP7/USP47 inhibitor

SKU: orb1302939

Description

USP7/USP47 inhibitor

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1247825-37-1
• MW: 484.4
• Purity: 98.71%
• Formula: C₁₈H₁₁Cl₂N₃O₃S₃
• SMILES: CS(=O)(=O)c1ccc(NC(=O)c2cc(C#N)c(Sc3c(Cl)cncc3Cl)s2)cc1
• Target: DUB
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.13 mM);DMSO:45 mg/mL (92.9 mM)

Bioactivity

• Target IC50:
  USP47:1.0 μM(EC50)|USP7:0.42 Μm(EC50)
• In Vitro:
  USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC50 of 7.6 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, DUBs, Deubiquitinase, USP47, USP7, USP7/47 inhibitor-1, USP7/USP47 inhibitor, USP-7/USP47 inhibitor

Compound Identifiers

PubChem CID

51031028