Ursolic acid

SKU: orb1310349

Description

Ursolic acid (Prunol) is a pentacyclic triterpenoid isolated from plants like Rhododendron caprifolium. It exhibits a broad spectrum of research-relevant biological activities, including anti-tumor, anti-inflammatory, and anti-diabetic effects, as demonstrated in various in vitro and in vivo studies.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 77-52-1
• MW: 456.7
• Purity: >98%
• Formula: C₃₀H₄₈O₃
• SMILES: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
• Target: Autophagy,Endogenous Metabolite
• Solubility: Soluble in DMSO (up to 25 mg/ml with warming).

Bioactivity

• Target IC50:
  WI-38 cells:1.8 μM|4T1 cells:44.08 μM|Bel-7402 cells:64.64 μM|B16 cells:3.1 μM|CAPAN-1 cells:8.6 μM|Ca9-22 cells:5.9 μg/mL|ASPC1 cells:12.6 μM|THP-1 cells:9.1 μM|T24 cells:29.29 μM|Bcap37 cells:28.69 μM|A549 cells:11.4 μM|A375 cells:30.88 μM|AGS cells:20.6 μM|BGC-823 cells:> 10 μM|B16 F10 cells:20.08 μM
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• In Vivo:
  METHODS: To investigate the antidepressant-like effects, Ursolic acid (0.001-10 mg/kg, distilled water with 10% Tween 80) was orally administered to Swiss mice, and the TST, FST, or open-field test was performed 60 min later. RESULTS: Ursolic acid shortened the immobilization time in TST and FST.The antidepressant-like effect of Ursolic acid in TST may be mediated by the activation of dopamine D1 and D2 receptors interacting with the dopaminergic system.
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• In Vitro:
  METHODS: Embryonal carcinoma cells NTERA-2 and NCCIT were treated with Ursolic acid (1-50 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Concentration-dependent inhibition of NTERA-2 and NCCIT cell viability by Ursolic acid treatment. METHODS: Lung cancer cells H460 and H1975 were treated with Ursolic acid (5-20 nM) for 48 h. Apoptosis was detected by Flow cytometry. RESULTS: Ursolic acid significantly increased the percentage of Annexin V (+) apoptotic cells compared to control.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, NSC167406, NSC-167406, NSC4060, NSC-4060, NSC 167406, NSC 4060, inhibit, EndogenousMetabolite, Endogenous Metabolite, Inhibitor, Malol, Prunol, Ursolic acid, Urson

Compound Identifiers

PubChem CID

13073350