Urocortin III (human)

SKU: orb1981279

Description

Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system and periphery. It selectively binds to type 2 CRF receptors with dissociation constants (Ki values) of 13.5 nM for mouse CRF2β, 21.7 nM for rat CRF2α, and >100 nM for human CRF1, indicating a strong preference for CRF-R2 over CRF1. Additionally, Urocortin III (human) plays a crucial role in the somatostatin-dependent negative feedback mechanism regulating the secretion of Insulin (human).

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	357952-09-1
MW	4137.93
Formula	C₁₈₅H₃₀₇N₅₃O₅₀S₂
Target	CRFR

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

CRFR

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