UNC10217938A HCl

SKU: orb1708287

Description

UNC10217938A HCl is a 3-deazapteridine-based small molecule that enhances the activity of oligonucleotide therapeutics, including siRNA and antisense agents. It functions by modulating intracellular trafficking and promoting endosomal release, which improves efficacy in both in vitro and in vivo research applications.

Key Properties

• MW: 493.00
• Purity: 99.08% (May vary between batches)
• Formula: C₂₆H₂₉ClN₆O₂
• SMILES: O=C(NC1=NC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2C(NCCN(C)C)=C1)OCC.Cl
• Target: Others
• Solubility: DMSO:40 mg/mL (81.14 mM)

Bioactivity

• In Vivo:
  Systemic treatment with SSO623 followed by administration of UNC10217938A HCl (7.5 mg/kg; intravenous injection) produces distinct increases in EGFP fluorescence in liver, kidney and heart in EGFP654 mice.
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• In Vitro:
  UNC10217938A HCl strongly enhances luciferase induction in HelaLuc705 cells when used in the 5-25 µM range and are substantially more effective and potent than Retro-1. As compared to splice switching oligonucleotide (SSO) alone, UNC10217938A HCl provids a 60-fold enhancement at 10 µM and 220-fold at 20 µM, in contrast to a 11-fold enhancement for 100 µM Retro-1. UNC10217938A HCl can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A HCl also can enhance effects of uncharged morpholino oligonucleotides as well as negatively charged oligonucleotides. Exposure of cells to UNC10217938A HCl leads to a major reduction in co-localization of the TAMRA-oliogonucleotide with the late endosome marker Rab7, but had little effect on co-localization with the lysosomal marker LAMP-1. UNC10217938A HCl causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UNC7938 HCl, UNC10217938A HCl(1347749-97-6 Free base), UNC10217938A HCl, UNC10217938A HCl(1347749-97-6 Free base)

Compound Identifiers

PubChem CID

169553374