UNC-2170

SKU: orb1305400

Description

UNC-2170 (UNC2170 Maleate) is a small molecule ligand that selectively binds the methyl-lysine reader protein 53BP1. It is a valuable chemical probe for studying DNA damage response pathways in both cellular and biochemical assays, facilitating research in oncology and genome stability.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1648707-58-7
• MW: 313.23
• Formula: C₁₄H₂₁BrN₂O
• SMILES: CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
• Target: Others
• Solubility: DMSO:60 mg/mL (191.55 mM);Methanol:125 mg/mL (399.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.39 mM)

Bioactivity

• In Vitro:
  UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

double-strand DNA breaks, 53BP1, Kme readers, H4K20me2, tudor domain, UNC 2170, UNC 2170 Maleate, UNC2170, UNC-2170, UNC2170 Maleate, UNC-2170 Maleate

Compound Identifiers

PubChem CID

78673861