UIS4 Antibody

SKU: orb11636

Description

Goat polyclonal antibody to UIS4. UIS4 protein is expressed throughout liver stage development and localizes to the parasite vacuole (parasitophorous vacuole membrane).

Images & Validation

• Tested Applications: IF
• Dilution Range: IF:1:250-1:1,000
• Reactivity: Plasmodium
• Application Notes:
  The antibody solution should be gently mixed before use.

Key Properties

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: Antigen: Purified recombinant peptide produced in E. coli. Antigen Sequence: MNPEVREKFRIGKRIKEFDDVNTPQDISLINPVENPYPENSPENSPENSPEKYIEESHKHYTKRFLEQYTEPKPSDHTYSYSPTEEAYNTHYMASDTHEDYGKLFTDEHKDEINDNIVYHDELSDLVGEGNNVYNMENKSFGPYI
• Target: up-regulated in infective sporozoites gene 4
• Purification: Epitope affinity purified
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Polyclonal antibody supplied as a 200 or 500 µl (2 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

up-regulated in infective sporozoites gene 4

Gregory M. LaMonte, Pamela Orjuela-Sanchez, Lawrence Wang, Shangzhong Li, Justine Swann, Annie N. Cowell, Bing Yu Zou, Alyaa M. Abdel-Haleem Mohamed, Zaira Villa-Galarce, Marta Moreno, Carlos Tong-Rios, Joseph M. Vinetz, Nathan Lewis, Elizabeth A. Winzeler Dual RNAseq shows the human mucosal immunity protein, MUC13, is a hallmark of Plasmodium exoerythrocytic infection Nat Commun, 10, 488 (2017)

PubMed: 30700707

Applications

IF

Reactivity

Parasite

LaMonte, Gregory M. et al. Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection Nat Commun, 10, 488 (2019)

PubMed: 30700707

Favuzza, Paola et al. Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle Cell Host Microbe, 27, 642-658.e12 (2020)

PubMed: 32109369