UBCS039

SKU: orb1299599

Description

UBCS039 is a first-in-class synthetic activator of Sirtuin 6 (SIRT6) with an EC50 of 38 µM. This compound is a valuable research tool for studying SIRT6's roles in aging, metabolism, and DNA repair in cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 358721-70-7
• MW: 247.29
• Purity: 99.75% (May vary between batches)
• Formula: C₁₆H₁₃N₃
• SMILES: N1C(c2cccn2-c2ccccc12)c1cccnc1
• Target: Sirtuin|||Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.18 mM);DMSO:125 mg/mL (505.48 mM)

Bioactivity

• Target IC50:
  SIRT6:38 μM
• In Vitro:
  UBCS039 induced a time-dependent activation of autophagy in several human tumor cell lines, as evaluated by increased content of the lipidated form of LC3B by western blot and of autophagosomal puncta by microscopy analysis of GFP-LC3. UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy. At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway. Interestingly, antioxidants were able to completely counteract UBCS039-induced autophagy, suggesting that ROS burst had a key role in upstream events leading to autophagy commitment.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Inhibitor, inhibit, UBCS039, UBCS-039, UBCS 039, SIRT, Sirtuin

Compound Identifiers

PubChem CID

2803797