Tyrphostin AG 1296

SKU: orb1223290

Description

6,7-Dimethoxy-3-phenylquinoxaline is an ATP-competitive inhibitor of receptor kinase.

Key Properties

• CAS Number: 146535-11-7
• MW: 266.29
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₄N₂O₂
• SMILES: COc1cc2nc(cnc2cc1OC)c3ccccc3
• Target: EGFR
• Solubility: In Vitro: DMSO : 33.33 mg/mL (125.16 mM)

Bioactivity

• In Vivo:
  Animal model: Nud/nud mice are injected with A375R cells. Dosage: 40, 80 mg/kg. Administration: i.p. daily for two weeks. Result: Led to an intermediate level of tumor growth suppression at dose of 40 mg/kg, and significant inhibition of A375R tumor growth at dose of 80 mg/kg. Well tolerated by healthy mice without significant signs of overt toxicity or weight loss.
• In Vitro:
  Cell Viability Assay Cell line: PLX4032-resistant cell lines (A375R and SK-MEL-5R). Concentration: 0.625, 1.25, 5, 20 μM Incubation time: 72 h. Result: Reduced the viability of both PLX4032-sensitive and PLX4032-resistant cell lines. Apoptosis Analysis Cell line: A375R cells. Concentration: 2.5, 5, 10, 20 μM Incubation time: 48 h. Result: Induced dramatic apoptosis in A375R cells. Western blot analysis. Cell line: A375R cells. Concentration: 5, 20 μM. Incubation time: 2 h. Result: Inhibited phosphorylation of both PDGFR-α and PDGFR-β.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6,7-Dimethoxy-3-phenylquinoxaline

Quick Database Links

Gene Symbol

EGFR