TYA-018

SKU: orb2308733

Description

TYA-018 is a selective, orally bioavailable HDAC6 inhibitor developed for cardiovascular research. It exhibits cardioprotective effects by mitigating sarcomere damage and reducing Nppb expression, making it a valuable tool for in vivo and in vitro studies of dilated cardiomyopathy and heart failure mechanisms.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2653254-31-8
• MW: 434.87
• Purity: 98.64% (May vary between batches)
• Formula: C₁₅H₁₃ClF₂N₄O₃S₂
• SMILES: O=S(=O)(N(C=1C=CC=C(Cl)C1)CC2=NC=C(S2)C3=NN=C(O3)C(F)F)CC
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.59 mM);DMSO:80 mg/mL (183.96 mM)

Bioactivity

• In Vivo:
  In BAG3cKO mice, TYA-018 (15 mg/kg; oral gavage, daily, starting at 2 months old, for 8 weeks) conferred cardioprotection in mice. It significantly reduced Nppb expression to near wild-type levels.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC6, TYA 018, TYA018

Compound Identifiers

PubChem CID

156525534