Tulathromycin A

SKU: orb1223185

Description

Tulathromycin A, also known as Tulathromycin and CP-472295, is a macrolide antibiotic used to treat bovine respiratory disease (BRD) in cattle and swine respiratory disease in pigs.

Key Properties

• CAS Number: 217500-96-4
• MW: 806.09
• Purity: >98% (HPLC)
• Formula: C₄₁H₇₉N₃O₁₂
• SMILES: CCCNC[C@]1(O)[C@H](C)O[C@H](C[C@@]1(C)OC)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
• Target: Histamine Receptor
• Solubility: DMSO : ≥ 45 mg/mL; 55.83 mM

Bioactivity

• In Vivo:
  In the lungs of both A pleuropneumoniae-and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs.
• In Vitro:
  Tulathromycin A (Tulathromycin) represents the first member of a novel subclass of macrolides, known as triamilides. Tulathromycin A (0.02 to 2.0 mg/mL) induces time- and concentration-dependent apoptosis in neutrophils, which enhances their subsequent clearance by macrophages.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tulathromycin | Draxxin | Tulathromycin A | CP-472,295

Quick Database Links

Gene Symbol

Histamine Receptor