TTP-8307

SKU: orb1708314

Description

TTP-8307 is a broad-spectrum antiviral small molecule that suppresses rhinovirus, enterovirus, coxsackievirus B3, and poliovirus replication by inhibiting viral RNA synthesis. It serves as a useful research tool for studying the mechanisms and treatment of picornavirus infections in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 950225-08-8
• MW: 436.48
• Purity: 99.14% (May vary between batches)
• Formula: C₂₇H₂₁FN₄O
• SMILES: C(N[C@H](C)C1=CC=C(F)C=C1)(=O)C=2C=C(C=3NC(=NC3)C4=CC5=C(C=N4)C=CC=C5)C=CC2
• Target: DNA/RNA Synthesis|||HCV Protease
• Solubility: DMSO:80 mg/mL (183.28 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.56 mM)

Bioactivity

• Target IC50:
  Enteroviruses A16 and A21:5.34 μM (EC50)|Sabin poliovirus:0.85 μM (EC50)|CVB3 Nancy:1.2 μM (EC50)
• In Vitro:
  TTP-8307 targeted non-structural protein 3A and inhibited the replication of enterovirus B3 (CVB3 Nancy) with an EC50 of 1.2 μM. In addition, TTP-8307 inhibited the replication of three Sabin poliovirus strains, as well as enteroviruses A16 and A21, with EC50s of 0.85 and 5.34 μM, respectively.Meanwhile, TTP-8307 inhibited the replication of human rhinoviruses (HRVs) 2, 29, 39, 45, 63 and 85 was also inhibitory. Mutations in non-structural protein 3A caused resistance to TTP-8307, a novel enterovirus replication inhibitor. In addition, TTP-8307 inhibits OSBP-dependent viruses, including encephalomyelitis virus (EMCV) and hepatitis C virus (HCV).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNA/RNA SynthesisProtease, DNASynthesis, HCVProtease, HCV Protease, HCV, RNA Synthesis, RNASynthesis, TTP 8307, TTP8307, TTP-8307

Compound Identifiers

PubChem CID

16739062